Amyloid and tau accumulation precede CSF production decline in normal aging
نویسندگان
چکیده
منابع مشابه
CSF tau protein and FDG PET in patients with aging-associated cognitive decline and Alzheimer’s disease
INTRODUCTION In Alzheimer's disease (AD), accelerated neurofibrillary tangle formation occurs which is associated with increased tau protein release into the cerebrospinal fluid (CSF). Recent studies found significantly increased CSF tau already in patients at risk of developing AD, indicating its potential as a biochemical marker of AD. Cerebral glucose metabolism is reduced in frontotemporopa...
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ژورنال
عنوان ژورنال: Cerebrospinal Fluid Research
سال: 2009
ISSN: 1743-8454
DOI: 10.1186/1743-8454-6-s1-s38